Metabolism and metabolomics of ketamine: a toxicological approach

RJ Dinis-Oliveira - Forensic sciences research, 2017 - academic.oup.com
Ketamine is a phencyclidine derivative and a non-competitive antagonist of N-methyl-D-
aspartate (NMDA) receptor for which glutamate is the full agonist. It produces a functional …

The clinical toxicology of ketamine

LJ Schep, RJ Slaughter, M Watts, E Mackenzie… - Clinical …, 2023 - Taylor & Francis
Introduction Ketamine is a pharmaceutical drug possessing both analgesic and anaesthetic
properties. As an anaesthetic, it induces anaesthesia by producing analgesia with a state of …

Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part A: chemical analysis and drug use estimates

DR Baker, L Barron, B Kasprzyk-Hordern - Science of the total environment, 2014 - Elsevier
This paper presents, for the first time, community-wide estimation of drug and
pharmaceuticals consumption in England using wastewater analysis and a large number of …

The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use

SS Kalsi, DM Wood, PI Dargan - Emerging Health Threats Journal, 2011 - Taylor & Francis
Ketamine was originally synthesised for use as a dissociative anaesthetic, and it remains
widely used legitimately for this indication. However, there is increasing evidence of non …

Recreational ketamine-related deaths notified to the National Programme on Substance Abuse Deaths, England, 1997–2019

JM Corkery, WC Hung, H Claridge… - Journal of …, 2021 - journals.sagepub.com
Background: Ketamine is a phencyclidine derivative with dissociative anaesthetic properties.
Increasing numbers of individuals in England take ketamine recreationally. Information on …

Wastewater analysis to monitor spatial and temporal patterns of use of two synthetic recreational drugs, ketamine and mephedrone, in Italy

S Castiglioni, A Borsotti, I Senta… - Environmental science & …, 2015 - ACS Publications
Wastewater analysis was applied in a four-year monitoring study to assess temporal and
spatial patterns of ketamine and mephedrone use in the general population in Italy …

What urologists need to know about ketamine‐induced uropathy: a systematic review

D Castellani, GM Pirola, M Gubbiotti… - Neurourology and …, 2020 - Wiley Online Library
Aims Ketamine is a general anesthetic. Dissociative effects and low cost led ketamine
becoming an illegal recreational drug in young adults. Ketamine‐induced uropathy (KIU) is …

[HTML][HTML] Ketamine-induced apoptosis in normal human urothelial cells: a direct, N-methyl-d-aspartate receptor–independent pathway characterized by mitochondrial …

SC Baker, S Shabir, NT Georgopoulos… - The American journal of …, 2016 - Elsevier
Recreational abuse of ketamine has been associated with the emergence of a new bladder
pain syndrome, ketamine-induced cystitis, characterized by chronic inflammation and …

Direct coupling of solid phase microextraction with electrospray ionization mass spectrometry: a case study for detection of ketamine in urine

B Hu, B Zheng, D Rickert, GA Gómez-Ríos, B Bojko… - Analytica chimica …, 2019 - Elsevier
Electrospray ionization mass spectrometry (ESI-MS) is a commonly used technique for
analysis of various samples. Solid phase microextraction (SPME) is a simple and efficient …

[HTML][HTML] A revised excretion factor for estimating ketamine consumption by wastewater-based epidemiology–utilising wastewater and seizure data

P Du, Q Zheng, KV Thomas, X Li, PK Thai - Environment international, 2020 - Elsevier
The rate of drug excretion (excretion factor) is a critical parameter for monitoring drug
consumption in the population by wastewater-based epidemiology (WBE). Previous studies …