Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

The development of RAPTA compounds for the treatment of tumors

BS Murray, MV Babak, CG Hartinger… - Coordination Chemistry …, 2016 - Elsevier
Abstract Ruthenium (II)-arene RAPTA-type compounds have been extensively explored for
their medicinal properties. Herein a comprehensive review of this class of compounds is …

Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

W Liu, R Gust - Coordination Chemistry Reviews, 2016 - Elsevier
The clinical success of platinum-based chemotherapeutic agents was of enormous impact
on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti …

Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

W Liu, R Gust - Chemical Society Reviews, 2013 - pubs.rsc.org
The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-
containing complexes as potential anticancer drugs. Among these novel complexes, metal N …

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

B Bertrand, A Casini - Dalton Transactions, 2014 - pubs.rsc.org
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …

Designing organometallic compounds for catalysis and therapy

AL Noffke, A Habtemariam, AM Pizarro… - Chemical …, 2012 - pubs.rsc.org
Bioorganometallic chemistry is a rapidly developing area of research. In recent years
organometallic compounds have provided a rich platform for the design of effective catalysts …

Caffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties

B Bertrand, L Stefan, M Pirrotta, D Monchaud… - Inorganic …, 2014 - ACS Publications
A new series of gold (I) N-heterocyclic carbene (NHC) complexes based on xanthine ligands
have been synthesized and characterized by mass spectrometry, NMR, and X-ray diffraction …

New insights in Au-NHCs complexes as anticancer agents

M Porchia, M Pellei, M Marinelli, F Tisato… - European journal of …, 2018 - Elsevier
Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …

Comparative in vitro evaluation of N-heterocyclic carbene gold (I) complexes of the benzimidazolylidene type

R Rubbiani, S Can, I Kitanovic… - Journal of medicinal …, 2011 - ACS Publications
Gold (I) complexes with a 1, 3-diethylbenzimidazol-2-ylidene N-heterocyclic carbene (NHC)
ligand of the type NHC-Au-L (L=-Cl,-NHC, or-PPh3) were comparatively evaluated as …

Enzyme inhibition by metal complexes: concepts, strategies and applications

KJ Kilpin, PJ Dyson - Chemical Science, 2013 - pubs.rsc.org
Metal complexes are increasingly being used to inhibit enzymes. The reasons for this
increased interest arise from the special features that metal complexes offer, eg the facile …