Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species

XQ Chen, WC Mobley - Frontiers in Neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …

Synaptic impairment in Alzheimer's disease: a dysregulated symphony

S Forner, D Baglietto-Vargas, AC Martini… - Trends in …, 2017 - cell.com
Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease

S Tu, S Okamoto, SA Lipton, H Xu - Molecular neurodegeneration, 2014 - Springer
Alzheimer's disease (AD) is a devastating disease characterized by synaptic and neuronal
loss in the elderly. Compelling evidence suggests that soluble amyloid-β peptide (Aβ) …

Amyloid-β receptors: the good, the bad, and the prion protein

HH Jarosz-Griffiths, E Noble, JV Rushworth… - Journal of biological …, 2016 - ASBMB
Several different receptor proteins have been identified that bind monomeric, oligomeric, or
fibrillar forms of amyloid-β (Aβ)." Good" receptors internalize Aβ or promote its transcytosis …

Axon guidance proteins in neurological disorders

EY Van Battum, S Brignani, RJ Pasterkamp - The Lancet Neurology, 2015 - thelancet.com
Many neurological disorders are characterised by structural changes in neuronal
connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire …

Eph receptors and ephrins: therapeutic opportunities

A Barquilla, EB Pasquale - Annual review of pharmacology and …, 2015 - annualreviews.org
The e rythropoietin-p roducing h epatocellular carcinoma (Eph) receptor tyrosine kinase
family plays important roles in developmental processes, adult tissue homeostasis, and …

Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease

P Padmanabhan, A Kneynsberg, J Götz - Nature Reviews …, 2021 - nature.com
The synapse has emerged as a critical neuronal structure in the degenerative process of
Alzheimer disease (AD), in which the pathogenic signals of two key players—amyloid-β (Aβ) …

Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies

Y Chen, AKY Fu, NY Ip - Pharmacology & therapeutics, 2019 - Elsevier
Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the
elderly population, is characterized by progressive cognitive decline and pathological …

Cellular receptors of amyloid β oligomers (AβOs) in Alzheimer's disease

B Mroczko, M Groblewska, A Litman-Zawadzka… - International journal of …, 2018 - mdpi.com
It is estimated that Alzheimer's disease (AD) affects tens of millions of people, comprising not
only suffering patients, but also their relatives and caregivers. AD is one of age-related …

Amyloid‐β oligomers in cellular models of Alzheimer's disease

IC Fontana, AR Zimmer, AS Rocha… - Journal of …, 2020 - Wiley Online Library
Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in
Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to …