Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

The cardiac extracellular matrix (ECM) not only provides mechanical support, but also
transduces essential molecular signals in health and disease. Following myocardial …

The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts.
However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to …