Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

Hemophagocytic lymphohistiocytosis (HLH) is a rapidly progressing, life-threatening
syndrome characterized by excessive immune activation, often presenting as a complex …

Image-guided percutaneous cryoablation is an established minimally invasive oncologic
treatment. We hypothesized that cryoablation may modify the immune microenvironment …

Introduction Hypoxia is associated with unfavorable prognoses in melanoma patients, and
the limited response rates of patients to PD-1/PD-L1 blockade could be attributed to the …

This study sought to elucidate the mechanisms underlying the impact of the interferon
signaling pathway on Ferroptosis in tumor cells and its correlation with CD8+ T cell …

Microsatellite unstable colorectal cancer (MSI-CRC) can arise through germline mutations in
mismatch repair (MMR) genes in individuals with Lynch syndrome (LS), or sporadically …

Although immune checkpoint-based cancer immunotherapy has shown significant efficacy
in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is …

Cancer immunotherapy is often hindered by an immunosuppressive tumor
microenvironment (TME). Various strategies are being evaluated to shift the TME from an …

Cancer remains one of the major threats to public health. Traditional chemotherapy,
radiotherapy, and other anti-tumor therapies have numerous limitations in clinical treatment …

IRF1 is a transcription factor well known for its role in IFN signaling. Although IRF1 was
initially identified for its involvement in inflammatory processes, there is now evidence that it …