Artificial intelligence (AI) has been widely applied in drug discovery with a major task as
molecular property prediction. Despite booming techniques in molecular representation …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Opioids are the strongest analgesics available and are crucial in the treatment of acute and
chronic pain. The line between these critical medications and how they are used beyond …

Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the
treatment of pain, but activation of MOR with current opioid analgesics also produces …

Basic amines show broad bioactivity and remain a promising source of new medicines. The
direct photoalkylation of imines offers a promising strategy for complex amines. However …

The global “opioid crisis” has placed enormous pressure on the opioid ligand discovery
community to produce novel opioid analgesics with superior opioid-related adverse-effect …

Mitragynine pseudoindoxyl, a kratom metabolite, has attracted increasing attention due to its
favorable side effect profile as compared to conventional opioids. Herein, we describe the …

A systematic study of trends in the lipophilicity of prominent representatives of the opioid
family, including natural, semisynthetic, synthetic, and endogenous neuropeptide opioids, is …

The abuse of opioids has become one of the most serious concerns in the world. Opioid use
can cause serious adverse reactions, including respiratory depression, postoperative …

Abstract Ethnopharmacological relevance The Anthocleista species are used to treat pain,
inflammation, and stomach disorders, but the mechanism by which Anthocleista vogelii …