The potential therapeutic effect of human umbilical cord mesenchymal stem cell-derived exosomes in bronchopulmonary dysplasia

T Cheng, M Mao, Y Liu, L Xie, F Shi, H Liu, X Li - Life Sciences, 2024 - Elsevier
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants, with its
incidence rising due to improved survival rates of these infants. BPD results from a …

The emerging role of epigenetic regulation in the progression of silicosis

H Yin, Y Xie, P Gu, W Li, Y Zhang, Y Yao, W Chen… - Clinical …, 2022 - Springer
Silicosis is one of the most severe occupational diseases worldwide and is characterized by
silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are …

[HTML][HTML] Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A …

L Hou, Z Zhu, F Jiang, J Zhao, Q Jia, Q Jiang… - Ecotoxicology and …, 2023 - Elsevier
Silicosis is a progressive inflammatory disease with poorly defined mechanisms and limited
therapeutic options. Recent studies found that microRNAs (miRNAs) and circular RNAs …

miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO2-Induced Lung Fibrosis

P Li, X Hao, J Liu, Q Zhang, Z Liang, X Li… - International Journal of …, 2023 - mdpi.com
Silicosis is a refractory pneumoconiosis of unknown etiology that is characterized by diffuse
lung fibrosis, and microRNA (miRNA) dysregulation is connected to silicosis. Emerging …

[HTML][HTML] Silica-exposed macrophages-secreted exosomal miR125a-5p induces Th1/Th2 and Treg/Th17 cell imbalance and promotes fibroblast transdifferentiation

M Ding, C Zhang, W Wang, P Wang, Y Pei… - Ecotoxicology and …, 2023 - Elsevier
Until now, the specific pathogenesis of silicosis is not clear. Exosomal miRNAs, as a newly
discovered intercellular communication medium, play an important role in many diseases …

Revisiting the role of MicroRNAs in the pathogenesis of idiopathic pulmonary fibrosis

Z Zhou, Y Xie, Q Wei, X Zhang, Z Xu - Frontiers in Cell and …, 2024 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a prevalent chronic pulmonary fibrosis disease
characterized by alveolar epithelial cell damage, fibroblast proliferation and activation …

Macrophage derived miR-7219–3p-containing exosomes mediate fibroblast trans-differentiation by targeting SPRY1 in silicosis

Z Niu, L Wang, X Qin, Z Ye, B Xie, Y Hu - Toxicology, 2022 - Elsevier
Silicosis is one of the most serious occupational diseases with the main feature of
inflammatory cell infiltration, fibroblasts activation, and large deposition of extracellular …

MiR-148a-3p within HucMSC-Derived Extracellular Vesicles Suppresses Hsp90b1 to Prevent Fibroblast Collagen Synthesis and Secretion in Silica-Induced …

Q Jiang, J Zhao, Q Jia, H Wang, W Xue, F Ning… - International Journal of …, 2023 - mdpi.com
Silicosis is a fatal occupational respiratory disease caused by the prolonged inhalation of
respirable silica. The core event of silicosis is the heightened activity of fibroblasts, which …

Emodin inhibiting epithelial‐mesenchymal transition in pulmonary fibrosis through the c‐MYC/miR‐182‐5p/ZEB2 axis

J Yang, G Jiang, K Ni, L Fan, W Tong… - Phytotherapy …, 2023 - Wiley Online Library
Emodin is a natural anthraquinone compound, which is the main component found in the
traditional Chinese herb Polygonum cuspidatum. The anti‐fibrosis effects of Emodin have …

microRNA-130b-3p delivery by mesenchymal stem cells-derived exosomes confers protection on acute lung injury

X Wang, J Feng, H Dai, J Mo, B Luo, C Luo… - …, 2022 - Taylor & Francis
Objective Researchers have investigated miR-130b-3p in lung disease pathology, such as
lung fibrosis. The present study was performed to elucidate the miR-130b-3p-involved …