Host genetic factors are a major contributing factor to the inter‐individual variation observed
in response to human immunodeficiency virus (HIV) infection and are linked to resistance to …

Dendritic cells (DC s) are a diverse subset of innate immune cells that are key regulators of
the host response to human immunodeficiency virus‐1 (HIV‐1) infection. HIV‐1 directly and …

MHC class I (MHC-I) polymorphisms are associated with the outcome of some viral
infections and autoimmune diseases. MHC-I proteins present antigenic peptides and are …

Plasmacytoid dendritic cells (pDCs) are innate immune cells that are specialized to produce
interferon-alpha (IFNα) and participate in activating adaptive immune responses. Although …

Plasmacytoid dendritic cells (pDCs) are robust producers of IFNα and one of the first
immune cells to respond to SIV infection. To elucidate responses to early HIV-1 replication …

In chronic diseases, such as HIV infection, plasmacytoid dendritic cells (pDCs) are rendered
dysfunctional, as measured by their decreased capacity to produce IFN-α. In this study, we …

Since the 1990s we have known of the fascinating ability of a complex set of professional
antigen presenting cells (APCs; dendritic cells, monocytes/macrophages, and B …

HIV research has made rapid progress and led to remarkable achievements in recent
decades, the most important of which are combination antiretroviral therapies (cART) …

Highlights•A dysregulated pro-inflammatory state is present in both aging and HIV
infection.•Age-and HIV-related changes in TLR function may contribute to this …

Plasmacytoid dendritic cells (plasmacytoid DC, pDC) are major IFN-I producers and have
been shown to be affected by HIV through ill-defined mechanisms. In this study, we directly …