Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …

Staphylococcus aureus is a major pathogen that colonizes about 20% of the human
population. Intriguingly, this Gram-positive bacterium can survive and thrive under a wide …

Based on technical advances in the sequencing and synthesis of genetic components as
well as the genome, significant progress has recently been made in developing synthetic …

Cells in assemblages differentiate and perform distinct roles. Though many pathways of
differentiation are understood at the molecular level in multicellular eukaryotes, the …

Transcriptional factors are well studied in bacteria for their global interactions and the effects
they produce at the phenotypic level. Particularly, Bacillus subtilis has been widely …

The fitness effect of biological noise remains unclear. For example, even within clonal
microbial populations, individual cells grow at different speeds. Although it is known that the …

CsrA is a widely conserved, abundant small RNA binding protein that has been found in E.
coli and other Gram-negative bacteria where it is involved in the regulation of carbon …

By combining advanced omics technology and computational modeling, systems biologists
have identified and inferred thousands of regulatory events and system-wide interactions of …

In bacteria small regulatory RNAs (sRNAs) interact with their mRNA targets through non-
consecutive base-pairing. The loose base-pairing specificity allows sRNAs to regulate large …