Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK)
cascades is a common mechanism of signal transduction in many cellular processes. Four …

The transforming growth factor-β (TGF-β) superfamily encompasses a large group of soluble
extracellular proteins that are potent regulators of development in both vertebrates and …

The Hippo signalling pathway regulates cellular proliferation and survival, thus has profound
effects on normal cell fate and tumorigenesis,,. The pivotal effector of this pathway is YAP …

Animal development is characterized by signaling events that occur at precise locations and
times within the embryo, but determining when and where such precision is needed for …

Precise control of somatic stem cell proliferation is crucial to ensure maintenance of tissue
homeostasis in high-turnover tissues. In Drosophila, intestinal stem cells (ISCs) are essential …

Directed cell migrations are important for development, but the signaling pathways and
mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration …

Visualizing dynamics of kinase activity in living animals is essential for mechanistic
understanding of cell and developmental biology. We describe GFP-based kinase reporters …

Intestinal stem cells (ISCs) in the Drosophila adult midgut are essential for maintaining
tissue homeostasis and replenishing lost cells in response to tissue damage. Here we …

The study of regeneration would be aided greatly by systems that support large-scale
genetic screens. Here we describe a nonsurgical method for inducing tissue damage and …

Signaling between tissues is essential to form the complex, three-dimensional organization
of an embryo. Because many receptor tyrosine kinases signal through the RAS-MAPK …