Hyaluronan (HA) plays well-recognized mechanical and biological roles in articular cartilage
and synovial fluid, where it contributes to tissue structure and lubrication. An understanding …

Background Osteochondral lesions of the talus (OLT) are common after ankle trauma.
Studies have shown that bioactive substances, such as hyaluronic acid (HA), alone, or in …

Background Lameness is a debilitating condition in equine athletes that leads to more
performance limitation and loss of use than any other medical condition. There are a limited …

Up to 50% of individuals develop post-traumatic osteoarthritis (PTOA) within 10 years
following knee-joint injuries such as anterior cruciate ligament rupture or acute meniscal …

Post-traumatic osteoarthritis of the ankle (PTOA) is frequently observed following a
debilitating consequence of intra-articular ankle fractures. Numerous risk factors contribute …

Lubricin is an important boundary lubricant and chondroprotective glycoprotein in synovial
fluid. Both increased and decreased synovial fluid lubricin concentrations have been …

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a joint disease
caused by a lack of lubricin, resulting in failed lubrication and abnormal deposition at the …

Articular osteochondral defects are quite common in clinical practice, and tissue engineering
techniques can offer a promising therapeutic option to address this issue. The articular …

Objective Lubricin is increasingly being evaluated as an outcome measure in studies
investigating post-traumatic and naturally occurring osteoarthritis. However, there are …

Hyaluronic acid (HA), a glycosaminoglycan found in joint synovial fluid, is administered to
horses as an anti-inflammatory with lubrication properties. This experiment examined the …