Most antimalarials are based on basic N-heterocycles and possess amine functionalities.
Despite this, the role of basic nitrogen (BaN) in antimalarial drug design has not been …

Intestinal diseases caused by protistan parasites of the genera Giardia (giardiasis),
Entamoeba (amoebiasis), Cryptosporidium (cryptosporidiosis) and Blastocystis …

Microbes broadly constitute several organisms like viruses, protozoa, bacteria, and fungi
present in our biosphere. Fast-paced environmental changes have influenced contact of …

Cysteine proteases are important targets for the discovery of novel therapeutics for many
human diseases. From parasitic diseases to cancer, cysteine proteases follow a common …

Cryptosporidium species has been identified as an important pediatric diarrheal pathogen in
resource-limited countries, particularly in very young children (0–24 months). However, the …

Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …

Simple Summary Gut-associated protozoa are a heterogenous group of microbes that
frequently reside within humans. The role of commensal intestinal protozoa and their …

Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the
gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the …

Cysteine proteases, also known as thiol proteases, are a class of nucleophilic proteolytic
enzymes containing cysteine residues in the enzymatic domain. These proteases generally …

The critical step of Trichinella spiralis infection is that the muscle larvae (ML) are activated to
intestinal infective larvae (IIL) which invade the intestinal columnar epithelium to further …