Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …

Stem-cell fate can be influenced by metabolite levels in culture, but it is not known whether
physiological variations in metabolite levels in normal tissues regulate stem-cell function in …

It has long been the dream of biologists to map gene expression at the single-cell level. With
such data one might track heterogeneous cell sub-populations, and infer regulatory …

The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …

Nucleotides are required for a wide variety of biological processes and are constantly
synthesized de novo in all cells. When cells proliferate, increased nucleotide synthesis is …

In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-
enter the cell cycle and proliferate. To proliferate, cells must increase their uptake and …