Chitosan nanoparticles loading oxaliplatin as a mucoadhesive topical treatment of oral tumors: Iontophoresis further enhances drug delivery ex vivo

BN Matos, MN Pereira, MO Bravo… - International journal of …, 2020 - Elsevier
Tumors located in the oral mucosa are challenging to treat since surgery can lead to
aesthetic, speech, and salivation problems, radiotherapy alone is often ineffective, and …

New perspectives on the topical management of recurrent candidiasis

ACS Ré, JF Martins, M Cunha‐Filho… - Drug Delivery and …, 2021 - Springer
Candidiasis is a common opportunistic infection caused by fungi of the Candida genus that
affects mainly mucocutaneous tissues (eg, vaginal, oral, and mammary). This condition has …

Metronidazole loaded chitosan–phytic acid polyelectrolyte complex nanoparticles as mucoadhesive vaginal delivery system for bacterial vaginosis

R Nayak, J Halder, TK Rajwar, D Pradhan… - International Journal of …, 2024 - Elsevier
Bacterial vaginosis (BV) is a recurring infection that is difficult to treat due to the limited
bioavailability of antimicrobials. In this study, Metronidazole (MTZ)-loaded chitosan …

Fungal infection models: Current progress of ex vivo methods

P Maciel Quatrin, D Flores Dalla Lana… - Mycoses, 2019 - Wiley Online Library
Experimental alternative ex vivo models that simulate infectious processes in vivo are of
fundamental importance for the evaluation of new drugs, since in some cases, their …

[HTML][HTML] Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases

S Teworte, S Aleandri, JR Weber, M Carone… - European Journal of …, 2023 - Elsevier
Gynaecological health is a neglected field of research that includes conditions such as
endometriosis, uterine fibroids, infertility, viral and bacterial infections, and cancers. There is …

[HTML][HTML] Miconazole-loaded nanoparticles coated with hyaluronic acid to treat vulvovaginal candidiasis

ADR Teixeira, ADV Quaresma, RT Branquinho… - European Journal of …, 2023 - Elsevier
Miconazole-loaded nanoparticles coated with hyaluronic acid (miconazole-loaded
nanoparticles/HA) were developed to overcome the limitations of the conventional therapy of …

Lipid complex-itraconazole in thermosensitive mucoadhesive vaginal gel to enhance the effectiveness of therapy for vulvovaginal candidiasis: Formulation …

M Sukmawaty, Sartini, AD Permana… - Journal of …, 2023 - Springer
Purpose This study aimed to produce lipid complex-ITR (CL-ITR) to enhance the solubility of
ITR which is then made into an in situ vaginal gel to maximize the local therapeutic effect of …

Iontophoresis application for drug delivery in high resistivity membranes: nails and teeth

JF Martins Andrade, T da Cunha Miranda… - Drug Delivery and …, 2023 - Springer
Iontophoresis has been vastly explored to improve drug permeation, mainly for transdermal
delivery. Despite the skin's electrical resistance and barrier properties, it has a relatively high …

In vitro skin model for the evaluation of burn healing drug delivery systems

GN Barbalho, BN Matos, MELE Santo… - Journal of Drug Delivery …, 2021 - Elsevier
This study aims to develop an in vitro burnt skin model to be used in permeation
experiments during the research and development of topical formulations for wound healing …

[HTML][HTML] Preliminary Assessment of the Mucosal Toxicity of Tea Tree (Melaleuca alternifolia) and Rosemary (Rosmarinus officinalis) Essential Oils on Novel Porcine …

M Bertocchi, A Rigillo, A Elmi, D Ventrella… - International Journal of …, 2020 - mdpi.com
Antimicrobial resistance, an ever-growing global crisis, is strongly linked to the swine
production industry. In previous studies, Melaleuca alternifolia and Rosmarinus officinalis …