Targeted alpha therapy: progress in radionuclide production, radiochemistry, and applications
This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …
Targeted radium alpha therapy in the era of nanomedicine: in vivo results
G Trencsényi, C Csikos, Z Képes - International Journal of Molecular …, 2024 - mdpi.com
Targeted alpha-particle therapy using radionuclides with alpha emission is a rapidly
developing area in modern cancer treatment. To selectively deliver alpha-emitting isotopes …
developing area in modern cancer treatment. To selectively deliver alpha-emitting isotopes …
Alpha dose modeling in diffusing alpha‐emitters radiation therapy—Part I: single‐seed calculations in one and two dimensions
G Heger, A Roy, M Dumančić, L Arazi - Medical Physics, 2023 - Wiley Online Library
Abstract Background Diffusing alpha‐emitters Radiation Therapy (“DaRT”) is a new method,
presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies …
presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies …
[HTML][HTML] Initial safety and tumor control results from a “first-in-human” multicenter prospective trial evaluating a novel alpha-emitting radionuclide for the treatment of …
A Popovtzer, E Rosenfeld, A Mizrachi, SR Bellia… - International Journal of …, 2020 - Elsevier
Purpose Our purpose was to report the feasibility and safety of diffusing alpha-emitter
radiation therapy (DaRT), which entails the interstitial implantation of a novel alpha-emitting …
radiation therapy (DaRT), which entails the interstitial implantation of a novel alpha-emitting …
Alpha dose modeling in diffusing alpha‐emitters radiation therapy. Part II: Lattice studies
G Heger, M Dumančić, A Roy, L Arazi - Medical Physics, 2023 - Wiley Online Library
Background Diffusing alpha‐emitters radiation therapy (“DaRT”) is a new method, presently
in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies on …
in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies on …
Combining alpha radiation-based brachytherapy with immunomodulators promotes complete tumor regression in mice via tumor-specific long-term immune response
V Domankevich, A Cohen, M Efrati, M Schmidt… - Cancer Immunology …, 2019 - Springer
Diffusing alpha-emitters radiation therapy (DaRT) is the only known method for treating solid
tumors with highly destructive alpha radiation. More importantly, as a monotherapy, DaRT …
tumors with highly destructive alpha radiation. More importantly, as a monotherapy, DaRT …
Diffusing alpha-emitters radiation therapy in combination with temozolomide or bevacizumab in human glioblastoma multiforme xenografts
Y Nishri, M Vatarescu, I Luz, L Epstein… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma multiforme (GBM) is at present an incurable disease with a 5-year survival rate
of 5.5%, despite improvements in treatment modalities such as surgery, radiation therapy …
of 5.5%, despite improvements in treatment modalities such as surgery, radiation therapy …
Clinical evidence of abscopal effect in cutaneous squamous cell carcinoma treated with diffusing alpha emitters radiation therapy: a case report
S Bellia, G Feliciani, M Duca, M Monti, V Turri… - Journal of …, 2019 - termedia.pl
Purpose The abscopal effect (AE) is a sporadic event of tumor regression following
radiotherapy treatment observed at distance from irradiated site. For the first time, the term …
radiotherapy treatment observed at distance from irradiated site. For the first time, the term …
Diffusing alpha-emitters radiation therapy: approximate modeling of the macroscopic alpha particle dose of a point source
L Arazi - Physics in Medicine & Biology, 2020 - iopscience.iop.org
Diffusing alpha-emitters radiation therapy ('DaRT') is a new cancer-treatment modality,
which enables treating solid tumors by alpha particles. The treatment utilizes implantable …
which enables treating solid tumors by alpha particles. The treatment utilizes implantable …
RIG-1-like receptor activation synergizes with intratumoral alpha radiation to induce pancreatic tumor rejection, triple-negative breast metastases clearance, and …
V Domankevich, M Efrati, M Schmidt, E Glikson… - Frontiers in …, 2020 - frontiersin.org
Diffusing alpha-emitting radiation therapy (DaRT) employs intratumoral Ra-224-coated
seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside …
seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside …