Spontaneous neuronal activity in developing neocortical networks: from single cells to large-scale interactions

HJ Luhmann, A Sinning, JW Yang… - Frontiers in neural …, 2016 - frontiersin.org
Neuronal activity has been shown to be essential for the proper formation of neuronal
circuits, affecting developmental processes like neurogenesis, migration, programmed cell …

Early GABAergic circuitry in the cerebral cortex

HJ Luhmann, S Kirischuk, A Sinning, W Kilb - Current opinion in …, 2014 - Elsevier
Highlights•Functional GABAergic synapses are already present in the prenatal
neocortex.•The perinatal neocortex contains transient GABAergic circuits.•Cajal-Retzius …

GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo

K Kirmse, M Kummer, Y Kovalchuk, OW Witte… - Nature …, 2015 - nature.com
A large body of evidence from in vitro studies suggests that GABA is depolarizing during
early postnatal development. However, the mode of GABA action in the intact developing …

Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex

O Blanquie, JW Yang, W Kilb, S Sharopov, A Sinning… - Elife, 2017 - elifesciences.org
Programmed cell death widely but heterogeneously affects the developing brain, causing
the loss of up to 50% of neurons in rodents. However, whether this heterogeneity originates …

Functional bimodality in the brain networks of preterm and term human newborns

A Omidvarnia, P Fransson, M Metsäranta… - Cerebral …, 2014 - academic.oup.com
The spontaneous brain activity exhibits long-range spatial correlations detected using
functional magnetic resonance imaging (fMRI) signals in newborns when (1) long neuronal …

Spindle activity orchestrates plasticity during development and sleep

C Lindemann, J Ahlbeck, SH Bitzenhofer… - Neural …, 2016 - Wiley Online Library
Spindle oscillations have been described during early brain development and in the adult
brain. Besides similarities in temporal patterns and involved brain areas, neonatal spindle …

Astrocytes facilitate gabazine‐evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures

A Ahtiainen, B Genocchi… - Journal of …, 2024 - Wiley Online Library
Gamma‐aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the adult
brain that binds to GABA receptors and hyperpolarizes the postsynaptic neuron. Gabazine …

Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex

J Vargas-Ortiz, L Lin, VK Martinez, R Liu… - Nature …, 2025 - nature.com
Synchronous neuronal activity is a hallmark of the developing mouse primary
somatosensory cortex. While the patterns of synchronous neuronal activity in cortical layer …

Postnatal development of 2 microcircuits involving fast-spiking interneurons in the mouse prefrontal cortex

JM Yang, J Zhang, YQ Yu, S Duan, XM Li - Cerebral cortex, 2014 - academic.oup.com
Disturbed development of the parvalbumin-positive fast-spiking (FS) interneurons in the
prefrontal cortex (PFC) is closely associated with many neuropsychiatric disorders such as …

Mesoscale calcium imaging in vivo: evolution and contribution to developmental neuroscience

T Guillamón-Vivancos, D Vandael, D Torres… - Frontiers in …, 2023 - frontiersin.org
Calcium imaging is commonly used to visualize neural activity in vivo. In particular,
mesoscale calcium imaging provides large fields of view, allowing for the simultaneous …