The development of zebrafish paired fins and tetrapod forelimbs and hindlimbs show striking
similarities at the molecular level. In recent years, the zebrafish, Danio rerio has become a …

Developmental origins of the neural crest (NC), a quintessential and pluripotent vertebrate
cell type, has historically been a topic of extensive investigation but continues to remain …

During vertebrate development the dorsal gastrula or Spemann-Mangold organizer
orchestrates axis formation largely by limiting the ventralizing and posteriorizing activity of …

Split hand/foot malformation (SHFM) is a rare limb abnormality with clefting of the fingers
and/or toes. For many individuals, the genetic etiology is unknown. Through whole-exome …

Vertebrate limb induction is triggered in the lateral plate mesoderm (LPM) by a cascade of
signaling events originating in the axial mesoderm. While it is known that Fgf, Wnt and …

The blimp1/krox gene of Strongylocentrotus purpuratus, formerly krox1, encodes zinc finger
transcription factors which play a central role in both early and late endomesoderm …

The inner ear is a complex vertebrate sense organ, yet it arises from a simple epithelium, the
otic placode. Specification towards otic fate requires diverse signals and transcriptional …

The B-lymphocyte-inducing maturation protein (Blimp-1) gene encodes a zinc finger and
SET/PR domain-containing transcriptional factor. A number of functional studies in a variety …

In the zebrafish embryo, expression of the prdm1 and patched1 genes in adaxial cells is
indicative of their specification to give rise to slow twitch muscle fibers in response to …

Formation of paired limbs in vertebrate embryos has long been a particularly useful
paradigm for the study of pattern formation. Here, we show that Blimp-1, a SET domain and …