Etiology, epidemiology, and natural history

W Bushman - Urologic Clinics, 2009 - urologic.theclinics.com
Historically, benign prostatic hyperplasia (BPH) has been a major focus of urologic practice
and surgery. However, a simplistic causal relationship among prostatic enlargement …

Human prostate cancer risk factors

DG Bostwick, HB Burke, D Djakiew… - … Journal of the …, 2004 - Wiley Online Library
Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition

Q Zhang, S Liu, KR Parajuli, W Zhang, K Zhang, Z Mo… - Oncogene, 2017 - nature.com
Chronic inflammation has been associated with a variety of human cancers including
prostate cancer. Interleukin-17 (IL-17) is a critical pro-inflammatory cytokine, which has been …

Prostate carcinogenesis and inflammation: emerging insights

GS Palapattu, S Sutcliffe, PJ Bastian, EA Platz… - …, 2005 - academic.oup.com
Prostate cancer remains a significant health concern for men throughout the world. Recently,
there has developed an expanding multidisciplinary body of literature suggesting a link …

Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial

B Gurel, MS Lucia, IM Thompson Jr, PJ Goodman… - … , biomarkers & prevention, 2014 - AACR
Background: Chronic inflammation is hypothesized to influence prostate cancer
development, although a definitive link has not been established. Methods: Prostate cancer …

[HTML][HTML] Effect of high-dose intravenous vitamin C on inflammation in cancer patients

N Mikirova, J Casciari, A Rogers, P Taylor - Journal of translational …, 2012 - Springer
Background An inflammatory component is present in the microenvironment of most
neoplastic tissues. Inflammation and elevated C-reactive protein (CRP) are associated with …

Epidemiology of inflammation and prostate cancer

EA Platz, AM De Marzo - The Journal of urology, 2004 - Elsevier
PURPOSE: We provide an overview of some of the basic, clinical and epidemiological
research that has been conducted to investigate the potential role of chronic inflammation in …

Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase‐2, Bcl‐2, and cell proliferation in the glandular …

W Wang, A Bergh, JE Damber - The Prostate, 2004 - Wiley Online Library
Background Chronic inflammation has been suggested to be linked to the development and
progression of prostate cancer. An inflammatory microenvironment may support the …

Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatment

AM De Marzo, TL DeWeese, EA Platz… - Journal of cellular …, 2004 - Wiley Online Library
Prostate cancer is an increasing threat throughout the world. As a result of a demographic
shift in population, the number of men at risk for developing prostate cancer is growing …

The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study

GT MacLennan, R Eisenberg, RL Fleshman… - The Journal of …, 2006 - auajournals.org
Purpose: We investigated an association between chronic prostatic inflammation and
prostate carcinogenesis. Materials and Methods: Initial prostate needle biopsies from 177 …