Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

Abstract p53 protects mammals from neoplasia by inducing apoptosis, DNA repair and cell
cycle arrest in response to a variety of stresses. p53-dependent arrest of cells in the G1 …

During the past 20 years, several types of human papillomaviruses (HPVs) have been
identified that cause specific types of cancers. The etiology of cancer of the cervix has been …

Abstract Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family,
is an important regulator of basic cellular functions (eg, formation and control of cell …

Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and
integration of multiple signaling pathways to effect the optimal cellular response to changes …

Abstract The Human Papillomavirus (HPV) E6 protein is one of three oncoproteins encoded
by the virus. It has long been recognized as a potent oncogene and is intimately associated …

Human papillomaviruses (HPVs) are associated with a number of clinical conditions, of
which the most serious is cervical carcinoma. The E6 protein of the oncogenic, mucosal …

The papillomaviruses are small DNA viruses that encode approximately eight genes, and
require the host cell DNA replication machinery for their viral DNA replication. Thus …

Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches
that couple extracellular signals to various cellular responses. Rap1, the closest relative of …