With the constant threat of emergence of a novel influenza virus pandemic, there must be
continued evaluation of the molecular mechanisms that contribute to virulence. Although the …

Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

Influenza viruses are respiratory pathogens of public health concern worldwide with up to
650,000 deaths occurring each year. Seasonal influenza virus vaccines are employed to …

Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature.
The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit …

Neuraminidase is one of the two surface glycoproteins of influenza A and B viruses. It has
enzymatic activity that cleaves terminal sialic acid from glycans, and that activity is essential …

Better vaccines against influenza virus are urgently needed to provide broader protection
against diverse strains, subtypes, and types. Such efforts are assisted by the identification of …

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Neuraminidase (NA) is one of the two influenza virus surface glycoproteins, and antibodies
that target it are an independent correlate of protection. However, our current understanding …

There is growing appreciation for neuraminidase (NA) as an influenza vaccine target;
however, its antigenicity remains poorly characterized. In this study, we isolated three …

As high-throughput biochemical screens are both expensive and labor intensive,
researchers in academia and industry are turning increasingly to virtual-screening …