Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …

Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from
DNA repair defects were once thought to be limited to rare inherited mutations (such as …

Genomic analysis of paired tumor–normal samples and clinical data can be used to match
patients to cancer therapies or clinical trials. We analyzed 500 patient samples across …

Enabled by high-throughput sequencing approaches, epithelial cancers across a range of
tissue types are seen to harbor gene fusions as integral to their landscape of somatic …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …

Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill
cancer cells. However, damaged DNA is repaired involving poly-(ADP-ribose) polymerase-1 …

Background Poly-(ADP-Ribose)-Polymerase (PARP) inhibitors are becoming important
actors of anti-neoplasic agents landscape, with recent but narrow FDA's approvals for …

The accurate identification and stratified treatment of clinically significant early-stage
prostate cancer have been ongoing concerns since the outcomes of large international …

Simple Summary The past decade has seen the development and regulatory approval of a
large number of new treatment options for advanced prostate cancer. Despite this, the two …

Radiotherapy continues to be a primary modality in the treatment of cancer. In addition to
promoting apoptosis, radiation-induced DNA damage can promote autophagy and …