Regional specialization within the mammalian respiratory immune system

DPH van Konijnenburg, PA Nigrovic, I Zanoni - Trends in Immunology, 2024 - cell.com
The respiratory tract is exposed to infection from inhaled pathogens, including viruses,
bacteria, and fungi. So far, a comprehensive assessment that integrates common and …

mRNA vaccine-induced IgG mediates nasal SARS-CoV-2 clearance in mice

C Fricke, L Ulrich, J Kochmann, J Gergen… - … Therapy Nucleic Acids, 2024 - cell.com
Coronavirus disease 2019 (COVID-19) mRNA vaccines that have contributed to controlling
the SARS-CoV-2 pandemic induce specific serum antibodies, which correlate with …

[PDF][PDF] Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

S Kalimuddin, CYL Tham, YFZ Chan, SK Hang… - Nature …, 2025 - nature.com
T cells have been identified as correlates of protection in viral infections. However, the level
of vaccine-induced T cells needed and the extent to which they alone can control acute viral …

[PDF][PDF] Design of targeted antiviral polypeptides specific to SARS-CoV-2. Challenges and prospects

ON Shilova, ES Shilov, SM Deyev - Russ. Chem. Rev, 2024 - researchgate.net
A new coronavirus infection (COVID-19) was the first time reported in December 2019 and
spread worldwide in a matter of months. 1 The world COVID-19 epidemic spread throughout …

T cell responses to repeated SARS-CoV-2 vaccination and breakthrough infections in patients on TNF inhibitor treatment: a prospective cohort study

AS Wolf, KH Bjørlykke, HS Ørbo, S Bhandari… - …, 2024 - thelancet.com
Background Understanding cellular responses to SARS-CoV-2 immunisations is important
for informing vaccine recommendations in patients with inflammatory bowel disease (IBD) …

A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice

JB Case, S Sanapala, C Dillen, V Rhodes, C Zmasek… - Cell Host & Microbe, 2024 - cell.com
The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus
zoonoses have spurred the design of vaccines that can induce broad immunity against …

Intranasal Multiepitope PD‐L1‐siRNA‐Based Nanovaccine: The Next‐Gen COVID‐19 Immunotherapy

RC Acúrcio, R Kleiner, D Vaskovich‐Koubi… - Advanced …, 2024 - Wiley Online Library
The first approved vaccines for human use against severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) are nanotechnology‐based. Although they are modular …

Antibodies and complement are key drivers of thrombosis

K Stark, B Kilani, S Stockhausen, J Busse, I Schubert… - Immunity, 2024 - cell.com
Venous thromboembolism (VTE) is a common, deadly disease with an increasing incidence
despite preventive efforts. Clinical observations have associated elevated antibody …

T cell-mediated protection in absence of virus neutralizing antibodies

YA Alpizar, K Dallmeier - Nature Microbiology, 2025 - nature.com
T cell-mediated protection in absence of virus neutralizing antibodies | Nature Microbiology
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[HTML][HTML] Tissue-resident memory T cells contribute to protection against heterologous SARS-CoV-2 challenge

A Odle, M Kar, AK Verma, A Sariol, DK Meyerholz… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
New vaccine formulations are based on circulating strains of virus, which have tended to
evolve to more readily transmit human to human and to evade the neutralizing antibody …