Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Intense efforts are being undertaken to understand the pathophysiological mechanisms
triggered after brain ischemia and to develop effective pharmacological treatments …

An intact blood-brain barrier (BBB) limits entry of proinflammatory and neurotoxic blood-
derived factors into the brain parenchyma. The BBB is damaged in Alzheimer's disease …

Breast adipose tissue is an important contributor to the obesity–breast cancer link.
Extracellular vesicles (EVs) are nanosized particles containing selective cargo, such as …

Stem cell‐based therapies have been reported in protecting cerebral infarction‐induced
neuronal dysfunction and death. However, most studies used rat/mouse neuron as model …

Aging is the strongest known risk factor for Alzheimer's disease (AD). With the discovery of
the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of …

Abstract Ethnopharmacological relevance The Tibetan turnip (Brassica rapa L.) has a wide
array of medicine properties including heat-clearing, detoxifying and anti-hypoxia as listed in …

The conjugation/de-conjugation of S mall U biquitin-like Mo difier (SUMO) has been shown
to be associated with a diverse set of physiologic/pathologic conditions. The clinical …

Mitochondria not only produce energy in the form of ATP to support the activities of cells
comprising the neurovascular unit, but mitochondrial events, such as depolarization and/or …

Both CO2 retention, or hypercapnia, and skeletal muscle dysfunction predict higher mortality
in critically ill patients. Mechanistically, muscle injury and reduced myogenesis contribute to …