Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …

Cellular transformation and cancer progression is accompanied by changes in the metabolic
landscape. Master co-regulators of metabolism orchestrate the modulation of multiple …

Glucose metabolism enzymes and transporters play major role in cancer development and
metastasis. In this study, we discuss glucose metabolism, transporters, receptors, hormones …

Increasing evidence has confirmed that deubiquitinating enzymes play an important role in
lung cancer progression. In the current study, we investigated the expression profile of …

Reactive oxygen species (ROS) are important cellular second messengers involved in
various aspects of cell signaling. ROS are elevated in multiple types of cancer cells, and this …

Background HIV-1, like all viruses, is entirely dependent on the host cell for providing the
metabolic resources for completion of the viral replication cycle and the production of virions …

A well-characterized metabolic landmark for aggressive cancers is the reprogramming from
oxidative phosphorylation to aerobic glycolysis, referred to as the Warburg effect. Models …

Background Lipid accumulation has been highlighted in cancer development and
progression, but the exact mechanism remains unclear in renal cell carcinoma (RCC) …

Abnormal accumulation of lipids has been highlighted in the progression of clear cell renal
cell carcinoma (ccRCC). However, the underlying mechanism remains unclear. Emerging …