Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Detection of circulating tumor DNAs (ctDNAs) in cancer patients is an important component
of cancer precision medicine ctDNAs. Compared to the traditional physical and biochemical …

Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival
rate of less than 15%, despite significant advances in both diagnostic and therapeutic …

Simple Summary Apart from genetic changes, cancer is characterized by epigenetic
alterations, which indicate modifications in the DNA (such as DNA methylation) and histones …

Circulating tumor DNA (ctDNA) is now being extensively studied as it is a noninvasive “real-
time” biomarker that can provide diagnostic and prognostic information before, during …

The discovery of actionable driver mutations such as epidermal growth factor receptor
(EGFR) and microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) …

Shp1 is a cytosolic tyrosine phosphatase that regulates a broad range of cellular functions
and targets, modulating the flow of information from the cell membrane to the nucleus. While …

For individuals with advanced or metastatic non-small cell lung cancer (NSCLC), the primary
treatment is platinum-based doublet chemotherapy. Immune checkpoint inhibitors (ICIs) …

Recently, liquid biopsy based on detection of circulating nucleic acid (NA) biomarkers from
body fluids has emerged as a promising strategy for lung cancer monitoring. Considering …

Cancer is the second leading cause of death worldwide being responsible for 9.6 million
deaths in 2018. Epigenetic alterations are key in directing the aberrant expression of tumor …