Obesity: epidemiology, pathophysiology, and therapeutics

X Lin, H Li - Frontiers in endocrinology, 2021 - frontiersin.org
Obesity is a complex multifactorial disease that accumulated excess body fat leads to
negative effects on health. Obesity continues to accelerate resulting in an unprecedented …

Influence of maternal obesity on the long-term health of offspring

KM Godfrey, RM Reynolds, SL Prescott… - The lancet Diabetes & …, 2017 - thelancet.com
In addition to immediate implications for pregnancy complications, increasing evidence
implicates maternal obesity as a major determinant of offspring health during childhood and …

[HTML][HTML] Obesity, male infertility, and the sperm epigenome

JR Craig, TG Jenkins, DT Carrell, JM Hotaling - Fertility and sterility, 2017 - Elsevier
Obesity is a growing epidemic and a common problem among reproductive-age men that
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …

Epigenetics across the human lifespan

RR Kanherkar, N Bhatia-Dey, AB Csoka - Frontiers in cell and …, 2014 - frontiersin.org
Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis

JM Campbell, M Lane, JA Owens, HW Bakos - Reproductive biomedicine …, 2015 - Elsevier
This systematic review investigated the effect of paternal obesity on reproductive potential.
Databases searched were Pubmed, Ovid, Web of Science, Scopus, Cinahl and Embase …

Obesity and male infertility: Mechanisms and management

K Leisegang, P Sengupta, A Agarwal, R Henkel - Andrologia, 2021 - Wiley Online Library
Obesity is considered a global health problem affecting more than a third of the population.
Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus …

Gut microbiota, host organism, and diet trialogue in diabetes and obesity

V Lazar, LM Ditu, GG Pircalabioru, A Picu… - Frontiers in …, 2019 - frontiersin.org
The gastrointestinal tract with its microbiota is a complex, open, and integrated ecosystem
with a high environmental exposure. It is widely accepted that the healthy gut microbiotais …

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children …

RC Richmond, AJ Simpkin, G Woodward… - Human molecular …, 2015 - academic.oup.com
Maternal smoking during pregnancy has been found to influence newborn DNA methylation
in genes involved in fundamental developmental processes. It is pertinent to understand the …

Early life nutrition, epigenetics and programming of later life disease

MH Vickers - Nutrients, 2014 - mdpi.com
The global pandemic of obesity and type 2 diabetes is often causally linked to marked
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …

Epigenetics and human obesity

SJ Van Dijk, PL Molloy, H Varinli, JL Morrison… - International journal of …, 2015 - nature.com
Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …