Progress of microfluidic hydrogel‐based scaffolds and organ‐on‐chips for the cartilage tissue engineering

H Tolabi, N Davari, M Khajehmohammadi… - Advanced …, 2023 - Wiley Online Library
Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

[HTML][HTML] Organ-on-a-chip meets artificial intelligence in drug evaluation

S Deng, C Li, J Cao, Z Cui, J Du, Z Fu, H Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

[HTML][HTML] Emerging microfluidics for the modeling and treatment of arthritis

N Yang, C Sun, C Dong, Y Huang, Y Zhu, Z Gu - Engineered Regeneration, 2024 - Elsevier
Microfluidic is a technology that allows the precise control of fluid in a micro-channel. With its
advantages of high throughput and low cost, microfluidic technology has achieved good …

Controlling microenvironments with organs-on-chips for osteoarthritis modelling

LJY Ong, X Fan, A Rujia Sun, L Mei, YC Toh… - Cells, 2023 - mdpi.com
Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global
population, resulting in morbidity and lower quality of life for patients. The study of OA …

Novel insights of EZH2-mediated epigenetic modifications in degenerative musculoskeletal diseases

Z Ma, L Chen, Y Wang, S Zhang, J Zheng, Y Luo… - Ageing Research …, 2023 - Elsevier
Abstract Degenerative musculoskeletal diseases (Osteoporosis, Osteoarthritis,
Degenerative Spinal Disease and Sarcopenia) are pathological conditions that affect the …

The protective effect of ergolide in osteoarthritis: In vitro and in vivo studies

X Meng, L Sun, X Meng, Q Bi - International Immunopharmacology, 2024 - Elsevier
Osteoarthritis (OA), a prevalent degenerative condition, occurs due to the deterioration of
joint tissues and cells. Consequently, safeguarding chondrocytes against damage caused …

The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis

X Zhang, R Su, H Wang, R Wu, Y Fan, Z Bin… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) affects millions of people worldwide, but there are limited drugs
available to treat it, so acquiring a more comprehensive comprehension of the underlying …

[HTML][HTML] A point-of-research decision in synovial tissue engineering: Mesenchymal stromal cells, tissue derived fibroblast or CTGF-mediated mesenchymal-to …

A Damerau, M Kirchner, P Mertins, F Buttgereit… - European Journal of …, 2024 - Elsevier
Rheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent inflammatory joint diseases
characterized by synovitis, cartilage, and bone destruction. Fibroblast-like synoviocytes …

Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment

Y Li, H Zhu, R Liu, Y Zhao, L Sun - Small Science, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is one of the leading causes of disability due to the autoimmune
destruction of synovial joints. Great efforts have been put into developing multifunctional …

Exploring Osteoarthritis Dynamics: Patient-Specific Cartilage Samples in an Organ-on-a-Chip Model

M Pasztorek, J Fischer, A Otahal, A de Luna… - Cartilage, 2024 - journals.sagepub.com
Objective This study aims to tackle the existing challenges associated with the prediction
and optimization of pharmaceutical interventions for osteoarthritis (OA). The primary …