The ubiquitin-proteasome system (UPS) has been implicated in neurodegenerative
diseases based on the presence of deposits consisting of ubiquitylated proteins in affected …

Many members of the heat shock protein family act in unison to refold or degrade misfolded
proteins. Some heat shock proteins also directly interfere with apoptosis. These homeostatic …

Cancer incidence is rising and this global challenge is further exacerbated by tumour
resistance to available medicines. A promising approach to meet the need for improved …

Aging has been associated with a progressive decline of proteostasis, but how this process
affects proteome composition remains largely unexplored. Here, we profiled more than …

Autophagic turnover of intracellular constituents is critical for cellular housekeeping, nutrient
recycling, and various aspects of growth and development in eukaryotes. Here we show that …

Damaged and misfolded proteins accumulate during the aging process, impairing cell
function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) …

Organisms that protect their germ-cell lineages from damage often do so at considerable
cost: limited metabolic resources become partitioned away from maintenance of the soma …

Embryonic stem cells can replicate continuously in the absence of senescence and,
therefore, are immortal in culture,. Although genome stability is essential for the survival of …

In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces
new proteasome synthesis promoted by the transcription factor RPN4. This ensures that …

Increased intracellular levels of α-synuclein are implicated in Parkinson's disease and
related disorders and may be caused by alterations in the ubiquitin–proteasome system …