Diabetic cardiomyopathy (DCM) is a cardiac dysfunction which affects approximately 12% of
diabetic patients, leading to overt heart failure and death. However, there is not an efficient …

Numerous epidemiological and pre-clinical studies have demonstrated that the
insulin/insulin-like growth factor (IGF) system plays a key role in the development and …

Background: Protein intake in early infancy has been suggested to be an important risk
factor for later obesity, but information on potential mechanisms is very limited. Objective …

In late twentieth century, Ruderman and Reaven showed that insulin resistance might be
fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related …

Summary Fibroblast growth factor 21 (FGF21) promotes insulin sensitivity but causes bone
loss. It elevates bone resorption by an undefined non-osteoclast-autonomous mechanism …

Background Certain individuals appear to be predisposed to recurrent pasture‐associated
laminitis. Previous studies have predominantly investigated risk factors only after disease …

The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …

OBJECTIVE: To compare the influence of dietary management and/or physical exercise on
ovarian function and metabolic variables in women with polycystic ovary syndrome (PCOS) …

Insulin-like growth factors (IGFs) circulate in extracellular fluids bound to a family of binding
proteins. Although they function in a classical manner to limit the access of the IGFs to their …

Biologically active proteins without stable tertiary structure are common in all known
proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to …