[HTML][HTML] Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis
Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …
interacting systems. In AD, skin inflammation is caused by host–environment interactions …
Interleukin‐13: targeting an underestimated cytokine in atopic dermatitis
T Bieber - Allergy, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been
considered a paradigmatic type 2 immunity (T2)‐driven disease. Interleukin (IL)‐4 and IL‐13 …
considered a paradigmatic type 2 immunity (T2)‐driven disease. Interleukin (IL)‐4 and IL‐13 …
[HTML][HTML] Type 2 immunity in tissue repair and fibrosis
Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …
immune response is commonly observed in tissues during allergic inflammation or infection …
[HTML][HTML] Tezepelumab, an anti–thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a …
EL Simpson, JR Parnes, D She, S Crouch… - Journal of the American …, 2019 - Elsevier
Background Tezepelumab (AMG 157/MEDI9929), a first-in-class monoclonal antibody,
targets thymic stromal lymphopoietin, a cytokine that is implicated in the pathogenesis of …
targets thymic stromal lymphopoietin, a cytokine that is implicated in the pathogenesis of …
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
TA Wynn, TR Ramalingam - Nature medicine, 2012 - nature.com
Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …
The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …
Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease
Background IgG 4-related disease (IgG 4-RD) is a systemic condition of unknown cause
characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T …
characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T …
[HTML][HTML] Lipid abnormalities in atopic skin are driven by type 2 cytokines
E Berdyshev, E Goleva, I Bronova, N Dyjack, C Rios… - JCI insight, 2018 - ncbi.nlm.nih.gov
Lipids in the stratum corneum of atopic dermatitis (AD) patients differ substantially in
composition from healthy subjects. We hypothesized that hyperactivated type 2 immune …
composition from healthy subjects. We hypothesized that hyperactivated type 2 immune …
Host responses in tissue repair and fibrosis
JS Duffield, M Lupher, VJ Thannickal… - Annual Review of …, 2013 - annualreviews.org
Myofibroblasts accumulate in the spaces between organ structures and produce
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …
[HTML][HTML] Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
K Kokubo, A Onodera, M Kiuchi, K Tsuji… - Frontiers in …, 2022 - frontiersin.org
Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host
defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 …
defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 …