[HTML][HTML] Noradrenergic neuromodulation in ageing and disease
F Krohn, E Lancini, M Ludwig, M Leiman… - Neuroscience & …, 2023 - Elsevier
The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …
Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions
The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a
lot of attention because of its emerging role in cognitive and psychiatric disorders. Although …
lot of attention because of its emerging role in cognitive and psychiatric disorders. Although …
Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer's disease
J Pahl, PC Prokopiou, E Bueichekú, AP Schultz… - Alzheimer's Research & …, 2024 - Springer
Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural
reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological …
reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological …
Association of intrinsic functional connectivity between the locus coeruleus and salience network with attentional ability
The locus coeruleus (LC) is a brainstem region associated with broad neural arousal
because of norepinephrine production, but it has increasingly been associated with specific …
because of norepinephrine production, but it has increasingly been associated with specific …
Cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals
F Deng, ME Dounavi, ERG Plini, K Ritchie… - Neurobiology of …, 2024 - Elsevier
Alzheimer's Disease (AD) neuropathology start decades before clinical manifestations, but
whether risk factors are associated with early cognitive and brain changes in midlife remains …
whether risk factors are associated with early cognitive and brain changes in midlife remains …
The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation
Z Chen, T Jiang, X Yin, B Li, Z Tan, J Guo - Frontiers in Neuroscience, 2023 - frontiersin.org
Background Insomnia disorder (ID) seriously affects the quality of people's daily life, and
acupuncture is an effective therapy for it. As an essential component of the upward activation …
acupuncture is an effective therapy for it. As an essential component of the upward activation …
Disrupted role of the connectivity between the locus coeruleus and the hippocampus in cognition of healthy, middle-aged individuals at risk of dementia: the …
It is well acknowledged that Alzheimer's Disease (AD) pathological processes start decades
before clinical manifestations, but the brain mechanism of sporadic AD in midlife remains …
before clinical manifestations, but the brain mechanism of sporadic AD in midlife remains …
A computer approach to assess age-related changes of the brain's white matter in Alzheimer Disease
Background Age is one of the major risk factors for Alzheimer's disease (AD) which is
considered the most common adult-onset dementia. There is little information about age …
considered the most common adult-onset dementia. There is little information about age …
Impact of Apolipoprotein E4 on the Locus Coeruleus Functional Connectivity in Preclinical Alzheimer's Disease
Background: Recent interest has surged in the locus coeruleus (LC) for its early involvement
in Alzheimer's disease (AD), notably concerning the apolipoprotein 4 allele (APOE4) …
in Alzheimer's disease (AD), notably concerning the apolipoprotein 4 allele (APOE4) …
Higher Cognitive Reserve Is Beneficial for Cognitive Performance Via Various Locus Coeruleus Functional Pathways in the Pre-Dementia Stage of Alzheimer's …
L Gong, K Chen, H Zhang, S Zhang, W Luo… - The Journal of …, 2024 - Springer
Background Cognitive reserve (CR) shows protective effects on cognitive function in older
adult and in Alzheimer's disease (AD). However, the brain mechanisms underlying the CR …
adult and in Alzheimer's disease (AD). However, the brain mechanisms underlying the CR …