The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

The coordination of nutrient sensing, delivery, uptake and utilization is essential for
maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be …

Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However,
during insulin resistance (IR), when insulin signalling is blunted and accompanied by …

The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes
hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with …

Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive
accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic …

Evidence suggests a close relationship between nonalcoholic fatty liver disease (NAFLD)
and type two diabetes (T2D). On the grounds of prevalence of disease, both conditions …