The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Hsp70s are among the most highly conserved proteins in all of biology. Through an iterative
binding and release of exposed hydrophobic residues on client proteins, Hsp70s can …

Castration-resistant prostate cancer (CRPC) is characterized by reactivation of androgen
receptor (AR) signaling, in part by elevated expression of AR splice variants (ARv) including …

Cancer cells rely on the chaperone heat shock protein 70 (Hsp70) for survival and
proliferation. Recently, benzothiazole rhodacyanines have been shown to bind an allosteric …

CRYAB is a member of the small heat shock protein family, first discovered in the lens of the
eye, and involved in various diseases, such as eye and heart diseases and even cancers …

The molecular chaperones are central mediators of protein homeostasis. In that role, they
engage in widespread protein–protein interactions (PPIs) with each other and with their" …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an
inactive conformation. They are released in the presence of androgens, enabling …

Overexpression and aggregation of α-synuclein (ASyn) are linked to the onset and
pathology of Parkinson's disease and related synucleinopathies. Elevated levels of the …

Abstract Heat shock protein 70 (Hsp70) is a molecular chaperone and central regulator of
protein homeostasis (proteostasis). Paramount to this role is Hsp70's binding to client …