NEET proteins belong to a highly conserved group of [2Fe–2S] proteins found across all
kingdoms of life. Due to their unique [2Fesingle bond2S] cluster structure, they play a key …

The ubiquity, structural variation, and functional diversity of iron-sulfur (Fe-S) clusters in
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …

Pioglitazone, an FDA-approved compound, has been shown to target the novel
mitochondrial protein mitoNEET and produce short-term neuroprotection and functional …

Adolescent individuals exhibit great variability in cortical dynamics and behavioral
outcomes. The developing adolescent brain is highly sensitive to social experiences and …

Abstract Background Available treatments for Parkinson's disease (PD) are only partially or
transiently effective. Identifying existing molecules that may present a therapeutic or …

Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the
progression of diabetes, negatively impacting insulin production and secretion from …

Women with diabetes mellitus are believed to have increased risk of developing breast
cancer and lower life expectancies. This study aims to depict the association between the …

Using the Quantum Theory of Atoms in Molecules, the average electron density (AED) tool
was developed and employed to quantitatively evaluate the similarities between bioisosteric …

Human NEET proteins contain two [2Fe–2S] iron–sulfur clusters, bound to three Cys
residues and one His residue. They exist in two redox states. Recently, these proteins have …

MitoNEET is a [2Fe-2S] redox active mitochondrial protein belonging to the CDGSH iron–
sulfur domain (CISD) family of proteins. MitoNEET has been implicated as a potential target …