Application and synthesis of thiazole ring in clinically approved drugs

ZX Niu, YT Wang, SN Zhang, Y Li, XB Chen… - European Journal of …, 2023 - Elsevier
The development of heterocyclic derivatives has progressed considerably over the past few
decades, and many new agents of synthetic and natural origin have been produced. Among …

Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

An overview of the synthesis and antimicrobial, antiprotozoal, and antitumor activity of thiazole and bisthiazole derivatives

AM Borcea, I Ionuț, O Crișan, O Oniga - Molecules, 2021 - mdpi.com
Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of
synthetic compounds. Its diverse pharmacological activity is reflected in many clinically …

Electrochemical enaminone C–H thiolation/C–N amination cascade for thiazole synthesis and its diastereoselective dearomatization

H Guo, Y Liu, C Wen, JP Wan - Green Chemistry, 2022 - pubs.rsc.org
An electrochemical method for the synthesis of 2-aminothiazoles via aryl ring construction
using enaminones and thioureas is reported. The cascade enamine C–H thiolation and C–N …

Pyrazoline hybrids as promising anticancer agents: An up-to-date overview

D Matiadis, M Sagnou - International Journal of Molecular Sciences, 2020 - mdpi.com
Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have
attracted significant attention from organic and medicinal chemists due to their potent …

Identification of unique quinazolone thiazoles as novel structural scaffolds for potential gram-negative bacterial conquerors

J Wang, MF Ansari, CH Zhou - Journal of Medicinal Chemistry, 2021 - ACS Publications
A class of quinazolone thiazoles was identified as new structural scaffolds for potential
antibacterial conquerors to tackle dreadful resistance. Some prepared compounds exhibited …

Cyclohexane-1, 3-dione derivatives as future therapeutic agents for NSCLC: QSAR modeling, in silico ADME-Tox properties, and structure-based drug designing …

O Daoui, S Elkhattabi, M Bakhouch, S Belaidi… - ACS …, 2023 - ACS Publications
The abnormal expression of the c-Met tyrosine kinase has been linked to the proliferation of
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …

Coumarin‐containing hybrids and their antibacterial activities

D Feng, A Zhang, Y Yang, P Yang - Archiv der Pharmazie, 2020 - Wiley Online Library
Infections caused by Gram‐positive and‐negative bacteria are one of the foremost causes of
morbidity and mortality globally. Antibiotics are the mainstay of therapy for bacterial …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

An electrochemical-enabled cascaded cyclization of enaminones with potassium thiocyanate and alcohols to access 2-alkoxythiazoles

D Li, L Chen, Y Jin, X Wang, L Liu, Y Li, G Chen… - Green …, 2023 - pubs.rsc.org
An electrochemical-enabled three-component cascaded cyclization of enaminones with
potassium thiocyanate and alcohols to access 2-alkoxythiazoles has been developed under …