Huntington's disease (HD) is a chronic neurodegenerative disorder caused by an expansion
of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation …

Methylation of cytosine in CpG dinucleotides is the major DNA modification in mammalian
cells that is a key component of stable epigenetic marks. This modification, which on the one …

Background Deficiency in neuronal structural plasticity is involved in the development of
major depressive disorder. TWIST1, a helix-loop-helix transcription factor that is essential for …

Huntington's disease (HD) is a devastating and fatal monogenic neurodegenerative disorder
characterized by progressive loss of selective neurons in the brain and is caused by an …

Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption
is well established to have numerous intersections with the pathogenesis of progressive …

The cellular protein quality control machinery is important for preventing protein misfolding
and aggregation. Declining protein homeostasis (proteostasis) is believed to play a crucial …

Abstract Study Objectives Genetics impacts sleep, yet, the molecular mechanisms
underlying sleep regulation remain elusive. In this study, we built machine learning models …

Huntington's disease (HD) is caused by a CAG-repeat expansion mutation in the Huntingtin
(HTT) gene. It is characterized by progressive psychiatric and neurological symptoms in …

DNA methylation plays a crucial role in development, aging, degeneration of various tissues
and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation …

Exposure to diisodecyl phthalate (DIDP) during early pregnancy may be a risk factor for
depressive behavior in offspring. While ozone (O 3) exposure also raises the probability of …