The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum

S Guloksuz, J van Os - Psychological medicine, 2018 - cambridge.org
The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …

Psychotic experiences in the general population, a review; definition, risk factors, outcomes and interventions

L Staines, C Healy, H Coughlan, M Clarke… - Psychological …, 2022 - cambridge.org
Psychotic experiences (PE) are common in the general population, in particular in
childhood, adolescence and young adulthood. PE have been shown to be associated with …

Validity and utility of hierarchical taxonomy of psychopathology (HiTOP): I. Psychosis superspectrum

R Kotov, KG Jonas, WT Carpenter, MN Dretsch… - World …, 2020 - Wiley Online Library
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …

Psychosis as a transdiagnostic and extended phenotype in the general population

J Van Os, U Reininghaus - World Psychiatry, 2016 - Wiley Online Library
A large body of research indicates that weak expressions of positive psychotic symptoms
(“psychotic experiences”) can be measured in the general population, and likely represent …

Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective-and cross-sectional cohort studies

F Varese, F Smeets, M Drukker, R Lieverse… - Schizophrenia …, 2012 - academic.oup.com
Evidence suggests that adverse experiences in childhood are associated with psychosis. To
examine the association between childhood adversity and trauma (sexual abuse, physical …

An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from …

RJ Linscott, J Van Os - Psychological medicine, 2013 - cambridge.org
BackgroundThe psychosis-proneness–persistence–impairment model of psychotic disorder
incorporates notions of both phenomenological and temporal continuity (persistence) of …

Cost of disorders of the brain in Europe 2010

A Gustavsson, M Svensson, F Jacobi… - European …, 2011 - Elsevier
BACKGROUND: The spectrum of disorders of the brain is large, covering hundreds of
disorders that are listed in either the mental or neurological disorder chapters of the …

Childhood and adolescent psychotic experiences and risk of mental disorder: a systematic review and meta-analysis

C Healy, R Brannigan, N Dooley, H Coughlan… - Psychological …, 2019 - cambridge.org
BackgroundPsychotic experiences (PEs) are common in childhood and adolescence and
their association with mental disorders is well-established. We aim to conduct a quantitative …

The environment and schizophrenia

J Van Os, G Kenis, BPF Rutten - Nature, 2010 - nature.com
Psychotic syndromes can be understood as disorders of adaptation to social context.
Although heritability is often emphasized, onset is associated with environmental factors …

Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies

I Kelleher, D Connor, MC Clarke, N Devlin… - Psychological …, 2012 - cambridge.org
BackgroundPsychotic symptoms occur more frequently in the general population than
psychotic disorder and index risk for psychopathology. Multiple studies have reported on the …