Recent insights into the structure, regulation, and function of the V-ATPases

K Cotter, L Stransky, C McGuire, M Forgac - Trends in biochemical …, 2015 - cell.com
The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent proton pumps that acidify
intracellular compartments and are also present at the plasma membrane. They function in …

The V-ATPases in cancer and cell death

F Chen, R Kang, J Liu, D Tang - Cancer gene therapy, 2022 - nature.com
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

The function of V-ATPases in cancer

L Stransky, K Cotter, M Forgac - Physiological reviews, 2016 - journals.physiology.org
The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …

Targeting the lysosome in cancer

S Piao, RK Amaravadi - Annals of the New York Academy of …, 2016 - Wiley Online Library
Lysosomes are membrane‐bound intracellular organelles that receive macromolecules
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …

Natural products from myxobacteria: novel metabolites and bioactivities

J Herrmann, A Abou Fayad, R Müller - Natural product reports, 2017 - pubs.rsc.org
Covering: 2011–July 2016 Myxobacteria are a rich source for structurally diverse secondary
metabolites with intriguing biological activities. Here we report on new natural products that …

The curious case of vacuolar ATPase: regulation of signaling pathways

S Pamarthy, A Kulshrestha, GK Katara, KD Beaman - Molecular cancer, 2018 - Springer
Abstract The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the
intracellular and extracellular pH of cells. The structure of V-ATPase has been highly …

Errors in RNA-Seq quantification affect genes of relevance to human disease

C Robert, M Watson - Genome biology, 2015 - Springer
Background RNA-Seq has emerged as the standard for measuring gene expression and is
an important technique often used in studies of human disease. Gene expression …

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

B Whitton, H Okamoto, G Packham… - Cancer medicine, 2018 - Wiley Online Library
Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …

Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing

YA Jagtap, P Kumar, S Kinger, AR Dubey… - Frontiers in Cell and …, 2023 - frontiersin.org
The disturbance in mitochondrial functions and homeostasis are the major features of
neuron degenerative conditions, like Parkinson's disease, Amyotrophic Lateral Sclerosis …

Lysosomal biology in cancer

C Fennelly, RK Amaravadi - Lysosomes: Methods and Protocols, 2017 - Springer
Cells depend on the lysosome for sequestration and degradation of macromolecules in
order to maintain metabolic homeostasis. These membrane-enclosed organelles can …