X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …

Sexually dimorphic traits are common among mammals and are specified during
development through the deployment of sex-specific genetic programs. Because little is …

Retrotransposons mediate gene regulation in important developmental and pathological
processes. Here, we characterized the transient retrotransposon induction during …

In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …

In sexually reproducing organisms, life begins with the fusion of transcriptionally silent
gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as …

X-chromosome inactivation and X-upregulation are the fundamental modes of chromosome-
wide gene regulation that collectively achieve dosage compensation in mammals, but the …

Early in development, placental and marsupial mammals harbouring at least two X
chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of …

Mammalian embryogenesis relies on glycolysis and oxidative phosphorylation to balance
the generation of biomass with energy production. However, the dynamics of metabolic …

Background Single-cell technologies are transforming biomedical research, including the
recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits …