Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Most proteins assemble into multisubunit complexes. The persistence of these complexes
across evolutionary time is usually explained as the result of natural selection for functional …

Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …

Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules.
AR primarily is responsible for mediating the physiologic effects of androgens by binding to …

The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …

The endocrine-disrupting activities of bisphenol A (BPA) and 19 related compounds were
comparatively examined by means of different in vitro and in vivo reporter assays. BPA and …