JNK signaling: regulation and functions based on complex protein-protein partnerships
A Zeke, M Misheva, A Reményi… - … and Molecular Biology …, 2016 - Am Soc Microbiol
The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
[HTML][HTML] The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation
The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …
Androgen receptor function and androgen receptor–targeted therapies in breast cancer: a review
Importance The androgen receptor (AR) pathway is emerging as a potential therapeutic
target in breast cancer. To date, AR-targeted drugs have been approved only for treatment of …
target in breast cancer. To date, AR-targeted drugs have been approved only for treatment of …
Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis
The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
A PDX/organoid biobank of advanced prostate cancers captures genomic and phenotypic heterogeneity for disease modeling and therapeutic screening
ML Beshiri, CM Tice, C Tran, HM Nguyen… - Clinical Cancer …, 2018 - AACR
Purpose: Prostate cancer translational research has been hampered by the lack of
comprehensive and tractable models that represent the genomic landscape of clinical …
comprehensive and tractable models that represent the genomic landscape of clinical …
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases
MA Bogoyevitch, B Kobe - Microbiology and Molecular Biology …, 2006 - Am Soc Microbiol
The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Androgen receptor variants occur frequently in castration resistant prostate cancer metastases
X Zhang, C Morrissey, S Sun, M Ketchandji, PS Nelson… - PloS one, 2011 - journals.plos.org
Background Although androgens are depleted in castration resistant prostate cancer
(CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated …
(CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated …
Mechanisms regulating protein localization
Cellular functions are dictated by protein content and activity. There are numerous strategies
to regulate proteins varying from modulating gene expression to post‐translational …
to regulate proteins varying from modulating gene expression to post‐translational …
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
F Claessens, S Denayer… - Nuclear receptor …, 2008 - journals.sagepub.com
Androgens control male sexual development and maintenance of the adult male phenotype.
They have very divergent effects on their target organs like the reproductive organs, muscle …
They have very divergent effects on their target organs like the reproductive organs, muscle …