DNA must be accurately copied and propagated from one cell division to the next, and from
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …

In response to genotoxic insults, cells activate DNA damage response pathways that either
stimulate transient cell cycle arrest and DNA repair or induce apoptosis. The Caenorhabditis …

CRISPR (clustered regularly interspaced short palindromic repeats)-based gene inactivation
provides a powerful means for linking genes to particular cellular phenotypes. CRISPR …

Azoospermia, which is the absence of spermatozoa in an ejaculate occurring due to defects
in sperm production, or the obstruction of the reproductive tract, affects about 1% of all men …

Gene inactivation through RNA interference (RNAi) has proven to be a valuable tool for
studying gene function in C. elegans. When combined with tissue-specific gene inactivation …

All cells rely on highly conserved protein folding and clearance pathways to detect and
resolve protein damage and to maintain protein homeostasis (proteostasis). Because age is …

The mechanisms governing apical membrane assembly during biological tube development
are poorly understood. Here, we show that extension of the C. elegans excretory canal …

Communication between neural cells and the vasculature is integral to the proper
development and later function of the central nervous system. A mechanistic understanding …

The purpose of this study was to determine important genes, functions, and networks
contributing to the pathobiology of cerebral cavernous malformation (CCM) from …

The various symptoms associated with hereditary defects in the DNA damage response
(DDR), which range from developmental and neurological abnormalities and …