Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Y Pan, W Tang, W Fan, J Zhang, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

Electromagnetic nanomedicines for combinational cancer immunotherapy

J Li, Y Luo, K Pu - Angewandte Chemie International Edition, 2021 - Wiley Online Library
Immunotherapy that harnesses the power of the immune system to eliminate malignant cells
has offered an effective approach for cancer treatment. However, limited patient response …

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

H Li, Q Luo, H Zhang, X Ma, Z Gu, Q Gong… - Chemical Society …, 2023 - pubs.rsc.org
Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …

The impact of radiation-induced DNA damage on cGAS-STING-mediated immune responses to cancer

Q Storozynsky, MM Hitt - International journal of molecular sciences, 2020 - mdpi.com
Radiotherapy is a major modality used to combat a wide range of cancers. Classical
radiobiology principles categorize ionizing radiation (IR) as a direct cytocidal therapeutic …

Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity

S Liu, W Wang, S Hu, B Jia, B Tuo, H Sun… - Cell Death & …, 2023 - nature.com
Cancer immunotherapy has transformed traditional treatments, with immune checkpoint
blockade being particularly prominent. However, immunotherapy has minimal benefit for …

[HTML][HTML] STING activation in cancer immunotherapy

T Su, Y Zhang, K Valerie, XY Wang, S Lin, G Zhu - Theranostics, 2019 - ncbi.nlm.nih.gov
Cancer immunotherapy modulates and leverages the host immune system to treat cancer.
The past decade has witnessed historical advancement of cancer immunotherapy. A myriad …

Development of an in situ cancer vaccine via combinational radiation and bacterial‐membrane‐coated nanoparticles

RB Patel, M Ye, PM Carlson, A Jaquish… - Advanced …, 2019 - Wiley Online Library
Neoantigens induced by random mutations and specific to an individual's cancer are the
most important tumor antigens recognized by T cells. Among immunologically “cold” tumors …

Advancements in prophylactic and therapeutic nanovaccines

P Bhardwaj, E Bhatia, S Sharma, N Ahamad… - Acta Biomaterialia, 2020 - Elsevier
Vaccines activate suitable immune responses to fight against diseases but can possess
limitations such as compromised efficacy and immunogenic responses, poor stability, and …