Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …
Electromagnetic nanomedicines for combinational cancer immunotherapy
Immunotherapy that harnesses the power of the immune system to eliminate malignant cells
has offered an effective approach for cancer treatment. However, limited patient response …
has offered an effective approach for cancer treatment. However, limited patient response …
Adjuvant physiochemistry and advanced nanotechnology for vaccine development
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation
Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …
oncology treatments, emerges in the current management of cancer. A growing number of …
The impact of radiation-induced DNA damage on cGAS-STING-mediated immune responses to cancer
Q Storozynsky, MM Hitt - International journal of molecular sciences, 2020 - mdpi.com
Radiotherapy is a major modality used to combat a wide range of cancers. Classical
radiobiology principles categorize ionizing radiation (IR) as a direct cytocidal therapeutic …
radiobiology principles categorize ionizing radiation (IR) as a direct cytocidal therapeutic …
Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity
S Liu, W Wang, S Hu, B Jia, B Tuo, H Sun… - Cell Death & …, 2023 - nature.com
Cancer immunotherapy has transformed traditional treatments, with immune checkpoint
blockade being particularly prominent. However, immunotherapy has minimal benefit for …
blockade being particularly prominent. However, immunotherapy has minimal benefit for …
[HTML][HTML] STING activation in cancer immunotherapy
Cancer immunotherapy modulates and leverages the host immune system to treat cancer.
The past decade has witnessed historical advancement of cancer immunotherapy. A myriad …
The past decade has witnessed historical advancement of cancer immunotherapy. A myriad …
Development of an in situ cancer vaccine via combinational radiation and bacterial‐membrane‐coated nanoparticles
Neoantigens induced by random mutations and specific to an individual's cancer are the
most important tumor antigens recognized by T cells. Among immunologically “cold” tumors …
most important tumor antigens recognized by T cells. Among immunologically “cold” tumors …
Advancements in prophylactic and therapeutic nanovaccines
Vaccines activate suitable immune responses to fight against diseases but can possess
limitations such as compromised efficacy and immunogenic responses, poor stability, and …
limitations such as compromised efficacy and immunogenic responses, poor stability, and …