Generation of circadian rhythms in the suprachiasmatic nucleus

MH Hastings, ES Maywood… - Nature Reviews …, 2018 - nature.com
The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …

Circadian time signatures of fitness and disease

J Bass, MA Lazar - Science, 2016 - science.org
Biological clocks are autonomous anticipatory oscillators that play a critical role in the
organization and information processing from genome to whole organisms. Transformative …

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome

S Risal, Y Pei, H Lu, M Manti, R Fornes, HP Pui… - Nature Medicine, 2019 - nature.com
How obesity and elevated androgen levels in women with polycystic ovary syndrome
(PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a …

New insights into the circadian rhythm and its related diseases

Y Xie, Q Tang, G Chen, M Xie, S Yu, J Zhao… - Frontiers in …, 2019 - frontiersin.org
Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …

Circadian system and glucose metabolism: implications for physiology and disease

J Qian, FAJL Scheer - Trends in Endocrinology & Metabolism, 2016 - cell.com
The circadian system serves one of the most fundamental properties present in nearly all
organisms: it generates 24-h rhythms in behavioral and physiological processes and …

The genetics of circadian rhythms, sleep and health

A Jagannath, L Taylor, Z Wakaf… - Human molecular …, 2017 - academic.oup.com
Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

Circadian photoentrainment in mice and humans

RG Foster, S Hughes, SN Peirson - Biology, 2020 - mdpi.com
Light around twilight provides the primary entrainment signal for circadian rhythms. Here we
review the mechanisms and responses of the mouse and human circadian systems to light …

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

A Jagannath, N Varga, R Dallmann, G Rando… - Nature …, 2021 - nature.com
The accumulation of adenosine is strongly correlated with the need for sleep and the
detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian …

Regulating the suprachiasmatic nucleus (SCN) circadian clockwork: interplay between cell-autonomous and circuit-level mechanisms

ED Herzog, T Hermanstyne… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …

Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations

WD Todd, A Venner, C Anaclet, RY Broadhurst… - Nature …, 2020 - nature.com
The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined
cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and …