The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Thyroid cancer is a common malignancy of endocrine system, and has now become the
fastest increasing cancer among all the malignancies. The development, progression …

Anaplastic thyroid carcinoma (ATC) is an extremely aggressive malignancy with
undifferentiated features, for which conventional treatments, including radioactive iodine …

Background Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine
kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and …

Thyroid cancer is the most common malignancy of the endocrine system with a steadily
rising incidence. The term “thyroid cancer” encompasses a spectrum of subtypes, namely …

Thyroid cancer is one of the most rapidly increasing malignancies. The reasons for this
increase is not completely known, but increases in the diagnosis of papillary thyroid …

Neuroendocrine (NE) cancers can cause significant patient morbidity. Besides surgery,
there are no curative treatments for NE cancers and their metastases, emphasizing the need …

Notch1-3 are transmembrane receptors that appear to be absent in medullary thyroid cancer
(MTC). Previous research has shown that induction of Notch1 has a tumor-suppressor effect …

Introduction: Thyroid cancer is an emerging public health concern. In the USA, its incidence
has doubled in the past decade, making it the eighth most commonly diagnosed neoplasm …

Carcinoids are slow-growing neuroendocrine tumors (NETs) that are characterized by
hormone overproduction; surgery is currently the only option for treatment. Activation of the …