Antimicrobial resistance: a concise update

CS Ho, CTH Wong, TT Aung… - The Lancet …, 2024 - thelancet.com
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a …

Antibiotic failure: Beyond antimicrobial resistance

C de la Fuente-Nunez, A Cesaro… - Drug Resistance Updates, 2023 - Elsevier
Despite significant progress in antibiotic discovery, millions of lives are lost annually to
infections. Surprisingly, the failure of antimicrobial treatments to effectively eliminate …

Peptide-based agents for cancer treatment: current applications and future directions

NTT Nhàn, T Yamada, KH Yamada - International Journal of Molecular …, 2023 - mdpi.com
Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

Deep learning tools to accelerate antibiotic discovery

A Cesaro, M Bagheri, M Torres, F Wan… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction As machine learning (ML) and artificial intelligence (AI) expand to many
segments of our society, they are increasingly being used for drug discovery. Recent deep …

Peptides from non-immune proteins target infections through antimicrobial and immunomodulatory properties

MDT Torres, A Cesaro, C de la Fuente-Nunez - Trends in Biotechnology, 2024 - cell.com
Encrypted peptides (EPs) have been recently described as a new class of antimicrobial
molecules. They have been found in numerous organisms and have been proposed to have …

Rational design of bioactive hydrogels toward periodontal delivery: from pathophysiology to therapeutic applications

Y Yin, S Yang, D Ai, H Qin, Y Sun, X Xia… - Advanced Functional …, 2023 - Wiley Online Library
Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in
periodontal tissue destruction. The design of functional biomaterials based on disease …

Peptide-derived ligands for the discovery of safer opioid analgesics

A Eliasof, LY Liu-Chen, Y Li - Drug discovery today, 2024 - Elsevier
Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the
treatment of pain, but activation of MOR with current opioid analgesics also produces …

Computational Approaches for Antimicrobial Peptide Delivery

TB Rios, SB Rezende, MR Maximiano… - Bioconjugate …, 2024 - ACS Publications
Peptides constitute alternative molecules for the treatment of infections caused by bacteria,
viruses, fungi, and protozoa. However, their therapeutic effectiveness is often limited by …

Unveiling a new chapter for collagen peptides: Comprehensive insights into oral bioavailability and the enhancement via encapsulation systems

Y Zhou, Y Jiang, Y Zhang, W Yokoyama, J Wu… - Trends in Food Science …, 2024 - Elsevier
Abstract Background Collagen peptides (CPs), valued for their health-promoting properties,
are increasingly used in nutritional supplements and functional foods. However, their …

Supramolecular Nano‐Grid Platform to Load and Deliver Liposomes and Exosomes

J Li, W Ma, X Ren, T Guo, B Yang, C Huang… - Small …, 2024 - Wiley Online Library
In general, carriers are designed to deliver pharmaceutical (featuring small drug‐molecules)
and biopharmaceutical (featuring large‐molecule drugs, eg, antibodies, proteins, etc.) active …