The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

In the present study, a novel pentapeptide LPLLR (Leu-Pro-Leu-Leu-Arg) was purified and
identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, and LC-MS/MS …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

The peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) is a
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …

The beating heart requires a constant flux of ATP to maintain contractile function, and there
is increasing evidence that energetic defects contribute to the development of heart failure …

The widespread epidemics of obesity and type 2 diabetes mellitus (T2DM) suggest that both
conditions are closely linked. An increasing body of evidence has shifted our view of …

Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of
life. The peripheral nervous system has an inherent capability to regenerate axons …

Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's
disease (AD) are characterized by the following hallmarks:(a) An exponential increase with …

Fatty liver disease is epidemiologically associated with type 2 diabetes (T2D), leading to a
speculation of a reciprocal cause–effect relationship and a vicious cycle of pathology. Here …