Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase
important in B‐lymphocyte development, differentiation, and signaling. Btk is a member of …

The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …

▪ Abstract The Tec family tyrosine kinases are now recognized as important mediators of
antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec …

Exquisite control of biological function is achieved via tight regulation of the catalytic and
binding activities of cellular proteins. The mechanistic details of protein regulation vary from …

Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function.
We present crystallographic and biochemical analyses of Btk, which together reveal …

Capturing the functionally relevant forms of dynamic, multidomain proteins is extremely
challenging. Bruton's tyrosine kinase (BTK), a kinase essential for B and mast cell function …

The Tec kinases represent the second largest family of mammalian non-receptor tyrosine
kinases and are distinguished by the presence of distinct proline-rich regions and pleckstrin …

The protein tyrosine kinases (PTKs) are enzymes catalyzing the transfer of the gamma-
phosphate group of ATP to the hydroxyl groups of specific tyrosine residues in peptides …

The Tec family kinase Itk plays a critical role in signal transduction downstream of the T cell
antigen receptor and has been implicated in the activation of phospholipase C-γ1, a key …

Pre–B cells undergo apoptosis unless they are rescued by pre–B cell receptor–dependent
survival signals. We previously showed that the BCR-ABL1 kinase that is expressed in pre …