ERK/MAPK signalling in the developing brain: Perturbations and consequences

JD Iroegbu, OK Ijomone, OM Femi-Akinlosotu… - Neuroscience & …, 2021 - Elsevier
The extracellular regulated kinase/microtubule-associated protein kinase (ERK/MAPK)
signalling pathway transduces signals that cause an alteration in the ongoing metabolic …

Antioxidants, hormetic nutrition, and autism

S Modafferi, G Lupo, M Tomasello… - Current …, 2024 - benthamdirect.com
Autism spectrum disorder (ASD) includes a heterogeneous group of complex
neurodevelopmental disorders characterized by atypical behaviors with two core …

Recurrent implication of striatal cholinergic interneurons in a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders

LA Poppi, KT Ho-Nguyen, A Shi, CT Daut… - Cells, 2021 - mdpi.com
Cholinergic interneurons are “gatekeepers” for striatal circuitry and play pivotal roles in
attention, goal-directed actions, habit formation, and behavioral flexibility. Accordingly …

Recent developments in autism genetic research: A scientometric review from 2018 to 2022

M Lim, A Carollo, D Dimitriou, G Esposito - Genes, 2022 - mdpi.com
Genetic research in Autism Spectrum Disorder (ASD) has progressed tremendously in
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …

[HTML][HTML] Autism NPCs from both idiopathic and CNV 16p11. 2 deletion patients exhibit dysregulation of proliferation and mitogenic responses

R Connacher, M Williams, S Prem, PL Yeung… - Stem Cell Reports, 2022 - cell.com
Neural precursor cell (NPC) dysfunction has been consistently implicated in autism. Induced
pluripotent stem cell (iPSC)-derived NPCs from two autism groups (three idiopathic [I-ASD] …

Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres

S Wang, L Wang, Q Bu, Q Wei, L Jiang, Y Dai… - Frontiers in …, 2023 - frontiersin.org
Introduction: Methamphetamine (METH) abuse by pregnant drug addicts causes toxic effects
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …

Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders

F Desprez, DC Ung, P Vourc'h, M Jeanne… - Frontiers in …, 2023 - frontiersin.org
The dihydropyrimidinase-like (DPYSL) proteins, also designated as the collapsin response
mediators (CRMP) proteins, constitute a family of five cytosolic phosphoproteins abundantly …

Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain

G Yoon, YH Lim, D Jo, J Ryu, J Song, YK Kim - Molecular psychiatry, 2021 - nature.com
Metabolic syndromes, including obesity, cause neuropathophysiological changes in the
brain, resulting in cognitive deficits. Only a few studies explored the contribution of non …

[HTML][HTML] Cullin-RING E3 ubiquitin ligase 4 regulates neurite morphogenesis during neurodevelopment

T Shim, JY Kim, WC Kim, YI Lee, B Cho, C Moon - Iscience, 2024 - cell.com
Neuritogenesis is crucial for establishing proper neuronal connections during brain
development; its failure causes neurodevelopmental defects. Cullin-RING E3 ubiquitin …

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation

MR Radler, X Liu, M Peng, B Doyle, K Toyo-Oka… - Current Biology, 2023 - cell.com
Pyramidal neurons are a major cell type of the forebrain, consisting of a pyramidally shaped
soma with axonal and apicobasal dendritic processes. It is poorly understood how the …