Ten years since the immune checkpoint inhibitor ipilimumab was approved for advanced
melanoma, it is time to reflect on the lessons learned regarding modulation of the immune …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …

Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is
active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism …

BACKGROUND Metabolic reprogramming is a hallmark of malignancy first recognized a
century ago. In some cases, reprogrammed metabolic activities can be exploited to …

Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet,
seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of …

Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …